A few of the things guaranteed to make me feel like giving up...
Sudden loud noises
Being told to be quiet
Condescending People
Extreme Physical Pain
Cruelty
Hiccups
Bugs that suck blood
Hair Tangles
Bad Parents
Hatred
Sitting/Stepping in Gum
Feeling Stupid
People ruled by the crowd
Being Misunderstood
Jammed Zippers
Losing
Smell of Vomit
Roadkill esp. intentional
Stifling heat
Broken Promises
Tight/Restricting clothing
Being outnumbered
Phony Socializing
Feeling Unclean
Wastefulness
Mildew
Embarrassments
Popular Bad Literature
Pointless Social Norms
Not having what I need when I need it
Anything Poorly Constructed
Popular Misconceptions
Itching
Being Wrong
Being Ill
Making Bad Mistakes
Cleaning up fecal matter
Having no control
Small, impossible buttons
People who destroy themselves
Sun burns
Hopelessness
Misplaced important belongings
Ending a relationship
Clumsiness
Bad Music
Forgetfulness
Feeling Cheated
Anything that Yaps
Sleeplessness
People who don’t argue well
So. Cal. Summer weather
Smog
Extreme Spelling/Grammatical errors
Ignorance
Bad Educators
Not Getting Mail
Loneliness
Overly sweet/salty foods
Poverty
Societal Roles
Authors who take publicity shots with pets or children
Jealousy
Missing out on Good Things
Anyone who can’t play fair
Not enough Privacy
When civilization forces itself on nature
Terror/Paranoia
Choking
A change in water temperature mid-shower